GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs13010639 | 1 | rs13025209 | chr2:231038169 | SP110 | chr2:231033645-231084827:- | 0.2 | 3.82 | 0.00014 | Obesity-related traits |
| BRCA | cis | rs13010639 | 1 | rs13025520 | chr2:231038029 | SP110 | chr2:231033645-231084827:- | 0.21 | 3.95 | 8.49E-5 | Obesity-related traits |
| BRCA | cis | rs13010639 | 1 | rs13026323 | chr2:231038403 | GPR55 | chr2:231772034-231825691:- | -0.13 | -3.43 | 0.000629 | Obesity-related traits |
| BRCA | cis | rs13010639 | 1 | rs13026323 | chr2:231038403 | SP110 | chr2:231033645-231084827:- | -0.21 | -4.06 | 5.33E-5 | Obesity-related traits |
| BRCA | cis | rs6547741 | 1 | rs13026621 | chr2:27807624 | KRTCAP3 | chr2:27665263-27667163:+ | -0.13 | -4.12 | 4.06E-5 | Oral cavity cancer |
| BRCA | cis | rs10205487 | 1 | rs13028508 | chr2:70118427 | ANXA4 | chr2:69969127-70053594:+ | 0.14 | 4.03 | 6.03E-5 | Carotid plaque burden (smoking interaction) |
| BRCA | cis | rs428445 | 1 | rs13037594 | chr20:55040168 | C20orf43 | chr20:55043647-55093942:+ | 0.16 | 4.32 | 1.72E-5 | Refractive astigmatism |
| BRCA | cis | rs11696845 | 1 | rs13037759 | chr20:43370692 | KCNK15 | chr20:43374488-43379666:+ | 0.13 | 4.51 | 7.33E-6 | Obesity-related traits |
| BRCA | cis | rs11696845 | 1 | rs13038016 | chr20:43370497 | KCNK15 | chr20:43374488-43379666:+ | 0.13 | 4.51 | 7.33E-6 | Obesity-related traits |
| BRCA | cis | rs911119 | 1 | rs13038305 | chr20:23610262 | CST1 | chr20:23728191-23731574:- | 0.21 | 4.62 | 4.34E-6 | Chronic kidney disease |
| BRCA | cis | rs7267979 | 1 | rs13038834 | chr20:25441433 | FAM182A | chr20:26035250-26067552:+ | -0.25 | -6.43 | 1.93E-10 | Liver enzyme levels (alkaline phosphatase) |
| BRCA | cis | rs7267979 | 1 | rs13038834 | chr20:25441433 | FAM182B | chr20:25744102-25848786:- | 0.23 | 5.78 | 9.94E-9 | Liver enzyme levels (alkaline phosphatase) |
| BRCA | cis | rs7267979 | 1 | rs13038834 | chr20:25441433 | PYGB | chr20:25228706-25278647:+ | -0.13 | -3.38 | 0.000738 | Liver enzyme levels (alkaline phosphatase) |
| BRCA | cis | rs911119 | 1 | rs13039536 | chr20:23612305 | CST1 | chr20:23728191-23731574:- | 0.22 | 4.69 | 3.07E-6 | Chronic kidney disease |
| BRCA | cis | rs911119 | 1 | rs13041070 | chr20:23614261 | CST1 | chr20:23728191-23731574:- | 0.23 | 4.81 | 1.7E-6 | Chronic kidney disease |